1. What Is Trioday?
Trioday (Cipla Ltd.) is a fixed-dose combination (FDC) antiretroviral pill for HIV-1 infection. One tablet, once daily — simplifies treatment, boosts adherence, and lowers pill burden.
2. What's Inside?
Ingredient Strength Class
Efavirenz 600 mg NNRTI
Lamivudine 300 mg NRTI
Tenofovir DF 300 mg NRTI
Packaging: White HDPE bottle, 30 tablets/box (30-day supply) .
Manufacturer: Cipla Limited, Goa, India . Distribution varies (e.g., Phil Pharmawealth in the Philippines).
3. How It Works
Three drugs, two classes, one goal — stop HIV from replicating.
Efavirenz (NNRTI): Binds directly to reverse transcriptase enzyme → prevents RNA-to-DNA conversion.
Lamivudine (NRTI): Mimics deoxycytidine → gets incorporated into viral DNA → chain termination.
Tenofovir (NRTI): Mimics adenosine monophosphate → active metabolite tenofovir diphosphate → chain termination.
Result: Synergistic viral suppression + lower resistance risk .
4. What It's For
Treating HIV-1 infection in adults .
Not a cure — chronic suppressive therapy.
Helps: reduce opportunistic infections, raise CD4 counts, improve quality of life .
5. Clinical Benefits
Benefit Details
Viral suppression Most patients reach <50 copies/mL
Immune recovery Significant CD4 increase
Better adherence Once-daily single tablet
Empty stomach, bedtime dosing Improves absorption & tolerability
6. Side Effects
Common (temporary, 2–4 weeks)
Neuro/psych: Dizziness, insomnia, poor concentration, abnormal dreams, headache, depression, anxiety
GI: Nausea, vomiting, diarrhea, abdominal pain
Other: Rash, fatigue, fever, cough, joint/muscle pain
Serious (rare – seek help immediately)
Lactic acidosis, fatty liver, hepatitis, liver failure
Kidney impairment, Fanconi syndrome, low bone density
Stevens-Johnson syndrome (severe rash)
Pancreatitis, IRIS
Red flags: Abdominal pain, dark urine, yellow skin/eyes, trouble breathing .
7. Who Should NOT Take Trioday?
Allergy to any ingredient
Severe liver disease
Certain interacting drugs (see section 8)
Special populations
Pregnancy: Causes birth defects → use effective contraception + 12 weeks after stopping. No breastfeeding .
Kidney disease: Tenofovir is renally excreted → monitor renal function .
Liver disease (HBV/HCV): Monitor closely.
Elderly (>65): Limited data.
8. Major Drug Interactions
Efavirenz affects CYP3A4 & CYP2B6. Avoid or monitor:
Drug Class Examples Risk
Antihistamines Astemizole, Terfenadine Cardiac arrhythmias
GI motility drugs Cisapride Cardiotoxicity
Ergot derivatives Ergotamine Ergot toxicity
Sedatives Midazolam, Triazolam Respiratory depression
Antipsychotics Pimozide Arrhythmias
Herbal St. John's Wort ↓ Trioday efficacy
Anticonvulsants Carbamazepine, Phenytoin Altered levels
Antifungals Ketoconazole ↓ Antifungal effect
Antibiotics Rifampin, Clarithromycin Multiple interactions
Avoid alcohol – worsens side effects & liver damage .
9. Dosage & Administration
Adult dose: 1 tablet once daily
How to take: Swallow whole, don't crush/chew
When: Empty stomach, preferably bedtime
Missed dose: Take ASAP unless next dose is near → no double doses
Overdose: Seek immediate medical help
10. Regulatory Status
Philippine FDA registration: DR-XY47585 (issued Dec 7, 2021; valid until Dec 7, 2024) .
Global access: Launched in Uganda (2015) to improve adherence .
11. Price (India)
₹2,365 – ₹3,455 per bottle of 30 tablets .
Generic substitutes: Avonza, Telura, Vonaday, Dinmek.
12. Patient Counseling Points (Quick Checklist)
# Advice
1 Take same time daily – don't skip doses
2 This is not a cure – use safe sex
3 Initial side effects improve in 2–4 weeks
4 Don't stop without doctor's advice
5 Regular blood tests (liver, kidney, viral load, CD4)
6 Avoid pregnancy + 12 weeks after stopping
7 Tell doctor all meds (including OTC & herbs)
13. read more Bottom Line
Trioday is a potent, convenient, affordable fixed-dose combination for HIV-1. It simplifies adherence, suppresses virus, and restores immunity. Not a cure, but a cornerstone of modern HIV care — especially in resource-limited settings where Cipla's pricing makes a difference.
Must be prescribed & monitored by a qualified healthcare professional.
References (Authentic & Unchanged)
Philippine Food and Drug Administration. (2024). *FDA Verification Portal - Product Information DR-XY47585*. https://verification.fda.gov.ph/
Farmako. (n.d.). Trioday Tablet - Uses, Side Effects, and Composition. https://farmako.in/
Oddway International. (2024). Trioday Tablets - Product Information. https://www.oddwayinternational.com/
Philippine Food and Drug Administration. (2021). *Human Drugs View - DR-XY47585*. https://verification.fda.gov.ph/
IndiaMART. (n.d.). *Trioday 30 Tablets - Product Details*. https://www.indiamart.com/
Oddway International. (2025). Efavirenz Lamivudine Tenofovir Tablets. https://www.oddwayinternational.com/
PharmEasy. (2025). Trioday Bottle of 30 Tablets. https://pharmeasy.in/
1mg. (n.d.). Trioday - Uses, Side Effects, Composition. https://www.1mg.com/
Antiaids.org. (2015). Uganda makes new AIDS drug. http://old.antiaids.org/